CASOCIDIN-I - A CASEIN-ALPHA(S2) DERIVED PEPTIDE EXHIBITS ANTIBACTERIAL ACTIVITY

被引:160
作者
ZUCHT, HD
RAIDA, M
ADERMANN, K
MAGERT, HJ
FORSSMANN, WG
机构
[1] Niedersächsisches Institut für Peptid-Forschung (IPF), D-30625 Hannover
来源
FEBS LETTERS | 1995年 / 372卷 / 2-3期
关键词
ANTIBACTERIAL; PEPTIDE; MILK; CASEIN; INTESTINAL FLORA;
D O I
10.1016/0014-5793(95)00974-E
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Here we report the isolation and characterization of an antibacterial peptide from bovine milk inhibiting the growth of Escherichia coli, and Staphylococcus carnosus. The primary structure of the peptide was revealed as a 39-amino-acid-containing fragment of bovine alpha(s2)-casein (position 165-203) by means of Edman amino acid sequencing and mass spectrometry, Since human milk does not contain any casein-alpha(s2), these findings could explain the different influence of human and bovine milk on the gastrointestinal flora of the suckling.
引用
收藏
页码:185 / 188
页数:4
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