THE UL37 PROTEIN OF HERPES-SIMPLEX VIRUS TYPE-1 IS ASSOCIATED WITH THE TEGUMENT OF PURIFIED VIRIONS

被引：46

作者：

SCHMITZ, JB

ALBRIGHT, AG

KINCHINGTON, PR

JENKINS, FJ

机构：

[1] UNIFORMED SERV UNIV HLTH SCI, DEPT MICROBIOL & IMMUNOL, BETHESDA, MD 20814 USA

[2] UNIV PITTSBURGH, DEPT OPHTHALMOL, PITTSBURGH, PA 15213 USA

[3] UNIV PITTSBURGH, DEPT MOLEC GENET & BIOCHEM, PITTSBURGH, PA 15213 USA

来源：

VIROLOGY | 1995年 / 206卷 / 02期

关键词：

D O I：

10.1006/viro.1995.1028

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The herpes simplex virus type 1 (HSV-1) UL37 open reading frame encodes a 120-kDa late (gamma 1) phosphoprotein in infected cells. Analysis of isolated mature HSV virions and light particles revealed that the UL37 protein is a component of the virion. Detergent solubilization and protease digestion experiments suggest that the UL37 protein is part of the tegument structure. Indirect immunofluorescence experiments using HSV-1-infected cells and cells infected with a vaccinia recombinant virus that expresses the UL37 gene demonstrated that the UL37 protein is present in both the nucleus and cytoplasm of infected cells and that localization to the nucleus does not require additional HSV proteins. (C) 1995 Academic Press, Inc.

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页码：1055 / 1065

页数：11

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