FLECAINIDE ENANTIOMERS - DISPOSITION IN HUMAN-SUBJECTS AND ELECTROPHYSIOLOGIC ACTIONS INVITRO

被引:20
作者
KROEMER, HK
TURGEON, J
PARKER, RA
RODEN, DM
机构
[1] VANDERBILT UNIV,DEPT PHARMACOL,NASHVILLE,TN 37232
[2] VANDERBILT UNIV,DEPT MED,NASHVILLE,TN 37232
[3] VANDERBILT UNIV,DEPT PREVENT MED,NASHVILLE,TN 37232
关键词
D O I
10.1038/clpt.1989.189
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:584 / 590
页数:7
相关论文
共 28 条
[1]   STEREOCHEMISTRY, A BASIS FOR SOPHISTICATED NONSENSE IN PHARMACOKINETICS AND CLINICAL-PHARMACOLOGY [J].
ARIENS, EJ .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 26 (06) :663-668
[2]  
BANNITT EH, 1986, J MED CHEM, V29, P299
[3]   IS THERE A GENETIC-FACTOR IN FLECAINIDE TOXICITY [J].
BECKMANN, J ;
HERTRAMPF, R ;
GUNDERTREMY, U ;
MIKUS, G ;
GROSS, AS ;
EICHELBAUM, M .
BRITISH MEDICAL JOURNAL, 1988, 297 (6659) :1316-1316
[4]  
BLASCHKE G, 1979, ARZNEIMITTEL-FORSCH, V29-2, P1640
[5]   VOLTAGE-DEPENDENT AND TIME-DEPENDENT DEPRESSION OF MAXIMUM RATE OF DEPOLARIZATION OF GUINEA-PIG VENTRICULAR ACTION-POTENTIALS BY 2 NEW ANTI-ARRHYTHMIC DRUGS, FLECAINIDE AND LORCAINIDE [J].
CAMPBELL, TJ ;
WILLIAMS, EMV .
CARDIOVASCULAR RESEARCH, 1983, 17 (05) :251-258
[6]   METABOLISM OF FLECAINIDE [J].
CONARD, GJ ;
OBER, RE .
AMERICAN JOURNAL OF CARDIOLOGY, 1984, 53 (05) :B41-B51
[7]   SUPPRESSION OF RESISTANT VENTRICULAR ARRHYTHMIAS BY TWICE DAILY DOSING WITH FLECAINIDE [J].
DUFF, HJ ;
RODEN, DM ;
MAFFUCCI, RJ ;
VESPER, BS ;
CONARD, GJ ;
HIGGINS, SB ;
OATES, JA ;
SMITH, RF ;
WOOSLEY, RL .
AMERICAN JOURNAL OF CARDIOLOGY, 1981, 48 (06) :1133-1140
[8]   ANTIARRHYTHMIC DRUG-ACTION - BLOCKADE OF THE INWARD SODIUM CURRENT [J].
GRANT, AO ;
STARMER, CF ;
STRAUSS, HC .
CIRCULATION RESEARCH, 1984, 55 (04) :427-439
[9]   CARDIAC ELECTROPHYSIOLOGIC EFFECTS OF FLECAINIDE ACETATE FOR PAROXYSMAL REENTRANT JUNCTIONAL TACHYCARDIAS [J].
HELLESTRAND, KJ ;
NATHAN, AW ;
BEXTON, RS ;
SPURRELL, RAJ ;
CAMM, AJ .
AMERICAN JOURNAL OF CARDIOLOGY, 1983, 51 (05) :770-778
[10]   TIME-DEPENDENT AND VOLTAGE-DEPENDENT INTERACTIONS OF ANTIARRHYTHMIC DRUGS WITH CARDIAC SODIUM CHANNELS [J].
HONDEGHEM, LM ;
KATZUNG, BG .
BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 472 (3-4) :373-398