A GENERAL-METHOD FOR CONTROLLING GLYCOSYLATION STEREOCHEMISTRY IN THE SYNTHESIS OF 2'-DEOXYRIBOSE NUCLEOSIDES

被引：73

作者：

WILSON, LJ ^{[1
]}

LIOTTA, D ^{[1
]}

机构：

[1] EMORY UNIV,DEPT CHEM,ATLANTA,GA 30322

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 13期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)98793-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Glycosylation reactions of 2-arylsulfinyl-O-acetylribosides6 with silylated thymine11 produce 2′-deoxyribose nucleosides with high β-selectivity. An application of this directing effect in the synthesis of the antiretroviral agent D4T,2, is described. © 1990 Pergamon Press plc.

引用

页码：1815 / 1818

页数：4

共 14 条

[1] KETENE ALKYLTRIALKYLSILYL ACETALS - SYNTHESIS, PRYOLYSIS AND NMR STUDIES [J].