INTERLEUKIN-1-BETA (IL-1-BETA) LEVELS IN GINGIVAL CREVICULAR FLUID FROM ADULTS WITH PREVIOUS EVIDENCE OF DESTRUCTIVE PERIODONTITIS - A CROSS-SECTIONAL STUDY

被引：74

作者：

WILTON, JMA ^{[1
]}

BAMPTON, JLM ^{[1
]}

GRIFFITHS, GS ^{[1
]}

CURTIS, MA ^{[1
]}

LIFE, JS ^{[1
]}

JOHNSON, NW ^{[1
]}

POWELL, JR ^{[1
]}

HARRAP, GJ ^{[1
]}

CRITCHLEY, P ^{[1
]}

机构：

[1] UNILEVER DENT RES,COLWORTH LAB,SHARNBROOK MK44 1LQ,BEDS,ENGLAND

来源：

JOURNAL OF CLINICAL PERIODONTOLOGY | 1992年 / 19卷 / 01期

关键词：

INTERLEUKIN-1-BETA; ADULT PERIODONTITIS; GINGIVAL CREVICULAR FLUID;

D O I：

10.1111/j.1600-051X.1992.tb01149.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

We have estimated the levels of Interleukin-1 beta (IL-1-beta) by ELISA in gingival crevicular fluid (GCF) at 58 sites from 37 patients with adult periodontitis. GCF was collected for 5 s on filter papers and a 2nd sample was collected for 30 s 1 min later. 68/116 strips yielded detectable levels of IL-1-beta. IL-1-beta was present in both the 1st and 2nd samples at 28 sites, in the 1st only at 4 sites and in the 2nd only at 8 sites; 18 sites were below the level of detection for the assay. When the concentrations of IL-1-beta were calculated in the original volume of GCF on each strip, the mean value for positive strips was 34.16 +/- 29.45 (SD) pg/mu-l with a range from 1.75 to 97.13 pg/mu-l. There were no statistically significant correlations with the plaque index, bleeding index or probeable crevice depth (pocket depth). The results indicate that IL-1 is present in the GCF from a proportion of sites with evidence of previous periodontal destruction.

引用

页码：53 / 57

页数：5

共 32 条

[1]

AINAMO J, 1982, INT DENT J, V32, P281

[2] CYTOKINES AS INFLAMMATORY MEDIATORS [J].

BILLINGHAM, MEJ .

BRITISH MEDICAL BULLETIN, 1987, 43 (02) :350-370

[3] INCREASED THYMOCYTE-ACTIVATING FACTOR IN HUMAN GINGIVAL FLUID DURING GINGIVAL INFLAMMATION [J].

CHARON, JA ;

LUGER, TA ;

MERGENHAGEN, SE ;

OPPENHEIM, JJ .

INFECTION AND IMMUNITY, 1982, 38 (03) :1190-1195

[4] THE TOTAL PROTEIN-CONCENTRATION OF GINGIVAL CREVICULAR FLUID - VARIATION WITH SAMPLING TIME AND GINGIVAL INFLAMMATION [J].

CURTIS, MA ;

GRIFFITHS, GS ;

PRICE, SJ ;

COULTHURST, SK ;

JOHNSON, NW .

JOURNAL OF CLINICAL PERIODONTOLOGY, 1988, 15 (10) :628-632

[5] THE PROTEIN-COMPOSITION OF GINGIVAL CREVICULAR FLUID SAMPLED FROM MALE-ADOLESCENTS WITH NO DESTRUCTIVE PERIODONTITIS - BASE-LINE DATA OF A LONGITUDINAL-STUDY [J].

CURTIS, MA ;

STERNE, JAC ;

PRICE, SJ ;

GRIFFITHS, GS ;

COULTHURST, SK ;

WILTON, JMA ;

JOHNSON, NW .

JOURNAL OF PERIODONTAL RESEARCH, 1990, 25 (01) :6-16

[6] BIOLOGY OF INTERLEUKIN-1 [J].

DINARELLO, CA .

FASEB JOURNAL, 1988, 2 (02) :108-115

[7]

EASTGATE JA, 1988, LANCET, V2, P706

[8] B-CELL-STIMULATORY FACTOR-II (BETA-2 INTERFERON) FUNCTIONS AS A 2ND SIGNAL FOR INTERLEUKIN-2 PRODUCTION BY MATURE MURINE T-CELLS [J].

GARMAN, RD ;

JACOBS, KA ;

CLARK, SC ;

RAULET, DH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) :7629-7633

[9] LPS-ELICITED SECRETORY RESPONSES IN MONOCYTES - ALTERED RELEASE OF PGE2 BUT NOT IL-1-BETA IN PATIENTS WITH ADULT PERIODONTITIS [J].

GARRISON, SW ;

NICHOLS, FC .

JOURNAL OF PERIODONTAL RESEARCH, 1989, 24 (02) :88-95

[10] CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF THE LIPOPOLYSACCHARIDE OF THE ORAL PATHOGEN WOLINELLA-RECTA ATCC-33238 [J].

GILLESPIE, J ;

WEINTRAUB, ST ;

WONG, GG ;

HOLT, SC .

INFECTION AND IMMUNITY, 1988, 56 (08) :2028-2035

← 1 2 3 4 →