MALATE-DEHYDROGENASE ISOENZYMES - CELLULAR LOCATIONS AND ROLE IN THE FLOW OF METABOLITES BETWEEN THE CYTOPLASM AND CELL ORGANELLES

被引：171

作者：

GIETL, C ^{[1
]}

机构：

[1] CARLSBERG LAB,DEPT PHYSIOL,COPENHAGEN,DENMARK

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1100卷 / 03期

关键词：

ORGANELLE TARGETING; GLYOXYLATE CYCLE; PHOTORESPIRATION; CRASSULACEAN ACID METABOLISM; MALATE DEHYDROGENASE; ENZYME LOCATION;

D O I：

10.1016/0167-4838(92)90476-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Malate dehydrogenases belong to the most active enzymes in glyoxysomes, mitochondria, peroxisomes, chloroplasts and the cytosol. In this review, the properties and the role of the isoenzymes in different compartments of the cell are compared, with emphasis on molecular biological aspects. Structure and function of malate dehydrogenase isoenzymes from plants, mammalian cells and ascomycetes (yeast, Neurospora) are considered. Significant information on evolutionary aspects and characterisation of functional domains of the enzymes emanates from bacterial malate and lactate dehydrogenases modified by protein engineering. The review endeavours to give up-to-date information on the biogenesis and intracellular targeting of malate dehydrogenase isoenzymes as well as enzymes cooperating with them in the flow of metabolites of a given pathway and organelle.

引用

页码：217 / 234

页数：18

共 203 条

[101] 2 MITOCHONDRIAL MATRIX PROTEASES ACT SEQUENTIALLY IN THE PROCESSING OF MAMMALIAN MATRIX ENZYMES [J].