PLASMA-CONCENTRATIONS OF PHYTO-ESTROGENS IN JAPANESE MEN

被引：623

作者：

ADLERCREUTZ, H ^{[1
]}

MARKKANEN, H ^{[1
]}

WATANABE, S ^{[1
]}

机构：

[1] NATL CANC CTR, RES INST, DIV EPIDEMIOL, TOKYO 104, JAPAN

来源：

LANCET | 1993年 / 342卷 / 8881期

关键词：

D O I：

10.1016/0140-6736(93)92188-Y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A low mortality from prostatic cancer is found in Japanese men consuming a low-fat diet with high content of soy products, a rich source of isoflavonoids. We therefore assayed four isoflavonoids in plasma of 14 Japanese and 14 Finnish men. The geometric mean plasma total individual isoflavonoid levels were 7 to 110 times higher in the Japanese than in the Finnish men. Genistein, a tyrosine kinase inhibitor, occurred in the highest concentration (geometric mean 276 nmol/L). We hypothesise that these high phyto-oestrogen levels may inhibit the growth of prostatic cancer in Japanese men, which may explain the low mortality from prostatic cancer in that country.

引用

页码：1209 / 1210

页数：2

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