APICAL EQUATORIAL ORIENTATION OF THE 6-MEMBERED RING IN P(V) MODELS OF ENZYMATICALLY FORMED CAMP-NUCLEOPHILE ADDUCTS - RELATIONSHIP TO THE BASIC HYDROLYSIS OF CAMP

被引：50

作者：

YU, JHH ^{[1
]}

SOPCHIK, AE ^{[1
]}

ARIF, AM ^{[1
]}

BENTRUDE, WG ^{[1
]}

机构：

[1] UNIV UTAH,DEPT CHEM,SALT LAKE CITY,UT 84112

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 11期

关键词：

D O I：

10.1021/jo00298a009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

: Results of a low-temperature 13C NMR study of 4, an X-ray crystal structure of 5, and 1H NMR results for 4 and 5 which show both model compounds to have the P(V) 1,3,2-dioxaphosphorinane ring attached apical/ equatorial to phosphorus and in a twist rather than chair conformation are reported and discussed relative to the enzymic and particularly the basic chemical hydrolysis of cAMP. © 1990, American Chemical Society. All rights reserved.

引用

页码：3444 / 3446

页数：3

共 20 条

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