THE OCCURRENCE OF VARIANT PH TRANSLOCATIONS IN CHRONIC MYELOID-LEUKEMIA (CML) - A REPORT OF 6 CASES

被引：5

作者：

KADAM, PR ^{[1
]}

NANJANGUD, GJ ^{[1
]}

ADVANI, SH ^{[1
]}

机构：

[1] TATA MEM HOSP,DEPT MED ONCOL,CYTOGENET LAB,DR E BORGES MARG,BOMBAY 400012,INDIA

来源：

HEMATOLOGICAL ONCOLOGY | 1990年 / 8卷 / 06期

关键词：

CML; VARIANT PH; VARIANT BREAKPOINTS;

D O I：

10.1002/hon.2900080602

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Variants of Philadelphia chromosome (Ph) translocation were detected in six of 95 Ph positive chronic myeloid leukemia (CML) patients (6.3 per cent). Two of these patients showed a Ph variant of 'simple' type, involving chromosomes 10 and 12. In four patients, the variant Ph was of 'complex' type involving a third chromosome:chromosomes 1, 6, 7 and 12 in addition to 9 and 22. Two of these resulted in the occurrence of a 'masked' Ph. In addition to variant Ph translocations, variant breakpoints such as q12 (two patients) and q13 (one patient) on chromosome 22 were observed in another three patients with t(9;22).

引用

页码：303 / 312

页数：10

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