CENTRALLY ADMINISTERED GALANIN INHIBITS OSMOTICALLY STIMULATED ARGININE VASOPRESSIN RELEASE IN CONSCIOUS RATS

被引：45

作者：

KONDO, K

MURASE, T

OTAKE, K

ITO, M

OISO, Y

机构：

[1] First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya

来源：

NEUROSCIENCE LETTERS | 1991年 / 128卷 / 02期

关键词：

GALANIN; ARGININE VASOPRESSIN; OPIOID; NALOXONE; OSMOTIC STIMULUS;

D O I：

10.1016/0304-3940(91)90271-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of centrally administered galanin on arginine vasopressin (AVP) release was investigated in conscious rats. Intracerebroventricular injection of porcine galanin suppressed hypertonic saline-induced increase in plasma AVP in a dose-dependent manner (12.5-100 pmol/rat) at 10 min after the injection. Pretreatment with subcutaneous injection of naloxone (1 mg/100 g b.wt.) partially blocked the galanin-induced effect on plasma AVP. These results suggest that central galanin inhibits osmotically stimulated AVP release and endogenous opioids are, at least in part, involved in the mechanism.

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页码：245 / 248

页数：4

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