SYNTHESIS AND ANTITUMOR-ACTIVITY OF 6-SUBSTITUTED PURINE AND DEAZAPURINE NUCLEOSIDES

被引：6

作者：

CRISTALLI, G

VITTORI, S

ELEUTERI, A

FRANCHETTI, P

GRIFANTINI, M

LUPIDI, G

CAPOLONGO, L

PESENTI, E

机构：

[1] UNIV CAMERINO,DIPARTMENTO BIOL CELLULAIRE,I-62032 CAMERINO,ITALY

[2] FARMITALIA CARLO ERBA SPA,MILAN,ITALY

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 1-3期

关键词：

D O I：

10.1080/07328319108046454

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of 6-hydroxylamino purine and deazapurine nucleosides were synthesized and tested for their antitumor and adenosine deaminase inhibitory activity. All the examined molecules displayed an in vitro activity comparable to that of the reference compounds HAPR and ara-A, their ID50 ranging from 0.9-mu-M (9) to approximately 100-mu-M (5).

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页码：253 / 257

页数：5

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