THYROID-ASSOCIATED OPHTHALMOPATHY

被引：47

作者：

WEETMAN, AP

机构：

[1] Department of Medicine, University of Sheffield, Clinical Sciences Centre, Northern General Hospital, Sheffield

来源：

AUTOIMMUNITY | 1992年 / 12卷 / 03期

基金：

英国惠康基金;

关键词：

GRAVES DISEASE; THYROID-ASSOCIATED OPHTHALMOPATHY; EYE MUSCLE;

D O I：

10.3109/08916939209148462

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Thyroid-associated ophthalmopathy (TAO) is one of the most vexing problems in endocrinology but its relationship to thyroid autoimmunity is becoming more clear with the realisation that almost all patients with Graves' disease have this condition and almost all patients with ophthalmopathy have some form of thyroid involvement. This suggests cross reactivity between thyroid and retrobulbar antigens, of which one potential candidate has recently been cloned. Together with new information on predisposing factors and the important role of the retrobulbar fibroblasts, these developments shed new light on the aetiology and pathogenesis of this enigmatic disorder. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：215 / 222

页数：8