DIRECT IMAGING OF MODIFIED BETA-CYCLODEXTRIN NANOSPHERES BY PHOTON SCANNING TUNNELING AND SCANNING FORCE MICROSCOPY

被引：11

作者：

SKIBA, M ^{[1
]}

PUISIEUX, F ^{[1
]}

DUCHENE, D ^{[1
]}

WOUESSIDJEWE, D ^{[1
]}

机构：

[1] UNIV PARIS 11,CTR PHARMACEUT,PHYSICOCHIM PHARMACOTECH & BIOPHARM LAB,CNRS,URA 1218,F-92290 CHATENAY MALABRY,FRANCE

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 120卷 / 01期

关键词：

CYCLODEXTRIN; NANOSPHERE; PHOTON SCANNING TUNNELING MICROSCOPY; SCANNING FORCE MICROSCOPY; SURFACE TOPOGRAPHY;

D O I：

10.1016/0378-5173(94)00349-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The morphological and topographical properties of nanospheres are of major importance for characterizing these systems. The quality, and consequently the applications, of such dispersions are determined by the mean particle size, their distribution by size and the topography of the nanospheres. This work is devoted to the application of contemporary analytical techniques: photon scanning tunnelling microscopy (PSTM), scanning force microscopy (SFM) and no-contact scanning force microscopy (NC-SFM) to image nanospheres prepared from chemically modified beta-cyclodextrins (PCD-C-6) without any sample preparation which could introduce artefacts. We have shown that the spherical geometry and high degree of monodispersity of nanospheres from beta CD-C-6 were confirmed by PSTM, but that NC-SFM was an excellent technique for the imaging of nanospheres prepared from beta CD-C-6.

引用

页码：1 / 11

页数：11

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