Infections in systemic lupus erythemotosus are frequent. However, osteoarticular Salmonella infections are rarely reported. We report a case of systemic lupus erythemomatosus diagnosed in a 15 year-old gir. Seven months later, she presented with fever and a localized collection of the upper extremity of the left tibia related to a Salmonella enteritidis acute osteomyelitis (sub periosteal abscess). The out-come was chronic and led to death. The authors emphasize the severity of non typhoidal salmonellosis in systemic lupus erythematosus.