SYNTHESIS OF IMMUNOGLOBULINS BY LYMPHOID-CELLS IN SHEEP - CONTRIBUTION MADE BY LYMPHOBLASTS TO TOTAL IMMUNOGLOBULIN AND ANTIBODY-PRODUCTION BY LYMPHOID-CELLS OF POPLITEAL NODE DURING A SECONDARY RESPONSE TO BACTERIAL LIPOPOLYSACCHARIDE

被引:7
作者
ENGLISH, LS [1 ]
MORRIS, B [1 ]
ADAMS, EP [1 ]
机构
[1] AUSTRALIAN NATL UNIV, JOHN CURTIN SCH MED RES, DEPT IMMUNOL, CANBERRA 2601, ACT, AUSTRALIA
关键词
D O I
10.1016/0008-8749(76)90234-3
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The production of immunoglobulin (Ig) and antibody by lymphoid cells of sheep popliteal lymph node was studied in vivo and in vitro during a secondary response to lipopolysaccharide extracted from Salmonella muenchen. The maximum production of Ig in vitro occurred on the 4th and 5th days of the response and the proportion of the Ig expressing affinity for the antigen was also maximal at this time. By infusing [3H]leucine into the node via a chronic fistula, it was possible to assess the relative contributions made by the blast cells to the total Ig production by the node at various times in the response. There were 3 phases of Ig production. The blast cell may be the primary antibody-producing cell involved in providing protection to the animal against the initial antigenic assault. The role of the plasma cell would be one of maintaining levels of specific antibody in the blood and extravascular spaces for a period of time after the main antigenic challenge has passed. Alternatively, the plasma cell may simply be an end cell.
引用
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页码:274 / 286
页数:13
相关论文
共 20 条
[1]  
CLAFLIN L, 1973, J IMMUNOL, V110, P252
[2]   ANTIBODY FORMATION BY SINGLE CELLS FROM LYMPH NODES AND EFFERENT LYMPH OF SHEEP [J].
CUNNINGHAM, AJ ;
SMITH, JB ;
MERCER, EH .
JOURNAL OF EXPERIMENTAL MEDICINE, 1966, 124 (04) :701-+
[3]   RECEPTORS ON IMMUNOCOMPETENT CELLS .5. CELLULAR CORRELATES OF MATURATION OF IMMUNE-RESPONSE [J].
DAVIE, JM ;
PAUL, WE .
JOURNAL OF EXPERIMENTAL MEDICINE, 1972, 135 (03) :660-&
[4]   IMMUNOLOGICAL MATURATION - PREFERENTIAL PROLIFERATION OF HIGH-AFFINITY PRECURSOR CELLS [J].
DAVIE, JM ;
PAUL, WE .
JOURNAL OF EXPERIMENTAL MEDICINE, 1973, 137 (01) :201-204
[5]   VARIATION IN AFFINITIES OF ANTIBODIES DURING IMMUNE RESPONSE [J].
EISEN, HN ;
SISKIND, GW .
BIOCHEMISTRY, 1964, 3 (07) :996-&
[6]   ROLE OF LYMPHOCYTES IN ANTIBODY-FORMATION .5. TRANSFER OF IMMUNOLOGICAL MEMORY TO TETANUS TOXOID - ORIGIN OF PLASMA-CELLS FROM SMALL LYMPHOCYTES, STIMULATION OF MEMORY CELLS IN-VITRO AND PERSISTENCE OF MEMORY AFTER CELL-TRANSFER [J].
ELLIS, ST ;
GOWANS, JL .
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1973, 183 (1071) :125-+
[7]   SYNTHESIS AND SECRETION OF IMMUNOGLOBULINS BY LYMPHOID-CELLS IN SHEEP - PRIMARY RESPONSE TO SALMONELLA LIPOPOLYSACCHARIDE [J].
ENGLISH, LS ;
ADAMS, EP ;
MORRIS, B .
JOURNAL OF EXPERIMENTAL MEDICINE, 1976, 144 (03) :586-603
[8]  
FAGRAEUS A, 1948, J IMMUNOL, V58, P1
[9]  
Fagraeus A, 1948, ACTA MED SCAND S, V130, P204
[10]   CHEMICAL COMPOSITION OF LIPOPOLYSACCHARIDE OF PSEUDOMONAS AERUGINOSA [J].
FENSOM, AH ;
GRAY, GW .
BIOCHEMICAL JOURNAL, 1969, 114 (02) :185-+