LIVER, BRAIN, AND HEART METALLOTHIONEIN INDUCTION BY STRESS

被引：68

作者：

HIDALGO, J ^{[1
]}

BORRAS, M ^{[1
]}

GARVEY, JS ^{[1
]}

ARMARIO, A ^{[1
]}

机构：

[1] SYRACUSE UNIV, DEPT BIOL, SYRACUSE, NY 13210 USA

来源：

JOURNAL OF NEUROCHEMISTRY | 1990年 / 55卷 / 02期

关键词：

Brain; Heart; Liver; Metallothionein; Stress; Zinc metabolism;

D O I：

10.1111/j.1471-4159.1990.tb04182.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To date, stress has been reported to induce metallothionein (MT) synthesis in the liver only. In the present experiment, the effects of food and water deprivation alone or of immobilization stress plus food and water deprivation on liver, brain, and heart MT have been studied in adult male rats. Liver and brain MT levels were increased by immobilization stress as soon as 6 h after the onset of stress. Eighteen hours of immobilization, which is accompanied by food and water deprivation, further increased liver and brain MT levels and significantly increased heart MT content. A specific effect of immobilization was evident in all three tissues, because the effect of food and water deprivation alone was significantly lower than that of immobilization plus starvation. Changes in MT apparently were not related to changes in cytosolic Zn. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：651 / 654

页数：4

共 18 条

[1] METALLOTHIONEIN GENE-EXPRESSION IN RATS - TISSUE-SPECIFIC REGULATION BY DIETARY COPPER AND ZINC [J].