CHRONIC RELAPSING MYALGIA (QUESTIONABLE POST VIRAL) - CLINICAL, HISTOLOGICAL, AND BIOCHEMICAL-STUDIES

Two patients with persistent myalgia characterised by onset after an ill-defined systemic illness, marked fluctuations in the severity of the symptoms and normal neuromuscular examination with the exception of variable muscle tenderness on deep palpation, may have a forme fruste of myalgic encephalomyelitis. Differentiation from psychogenic muscle pain is important in management. Muscle histology revealed non-specific type II fiber atrophy. Mitochrondrial respiration was assayed polarographically in intact organelles in vitro and revealed a mild depression of state 3 respiration rates with site I and site II substrates.