LACTATION ABOLISHES CORTICOTROPIN-RELEASING FACTOR-INDUCED OXYTOCIN SECRETION IN THE CONSCIOUS RAT

被引：37

作者：

PATEL, H ^{[1
]}

CHOWDREY, HS ^{[1
]}

LIGHTMAN, SL ^{[1
]}

机构：

[1] CHARING CROSS HOSP,CHARING CROSS & WESTMINSTER MED SCH,NEUROENDOCRINOL UNIT,LONDON W6 8RF,ENGLAND

来源：

ENDOCRINOLOGY | 1991年 / 128卷 / 02期

关键词：

D O I：

10.1210/endo-128-2-725

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have assessed the response of plasma oxytocin (OT) to intracerebroventricular CRF-41 in both virgin female and lactating rats. In virgin rats CRF-41 resulted in an increase in plasma OT from 5-30 min after administration. In lactating rats, however, there was a complete abolition of the OT response, even at the highest dose of CRF-41. These data demonstrate another feature of the hormone nonresponsiveness apparent during lactation and suggests that one of the reasons for the lack of stress responses could be a down-regulation of the response to endogenously released CRF-41.

引用

页码：725 / 727

页数：3

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