THE INFLUENCE OF CHLORPROMAZINE ON THE POTENTIAL-INDUCED SHAPE CHANGE OF HUMAN ERYTHROCYTE

被引：11

作者：

HARTMANN, J

GLASER, R

机构：

[1] Sektion Biologie, Bereich Biophysik, Humboldt-Universität zu Berlin, Berlin

来源：

BIOSCIENCE REPORTS | 1991年 / 11卷 / 04期

关键词：

ERYTHROCYTES; CELL SHAPE TRANSFORMATION; TRANSMEMBRANE POTENTIAL; CHLORPROMAZINE;

D O I：

10.1007/BF01136855

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of chlorpromazine (CPZ) on the shape of human erythrocytes with different values of transmembrane potential (TMP) was investigated. The shape of red blood cells with negative values of the TMP remained unchanged after the formation of stomatocytes by chlorpromazine, while cells with positive TMP showed a characteristic time course of shape change during the incubation with CPZ. Experiments with vanadate show that this might be due to a difference in the activity of the phospholipid-translocase at different values of TMP.

引用

页码：213 / 221

页数：9

共 22 条

[1] ION REGULATION OF PHOSPHATIDYLSERINE AND PHOSPHATIDYLETHANOLAMINE OUTSIDE INSIDE TRANSLOCATION IN HUMAN-ERYTHROCYTES [J].