STRUCTURE AND FUNCTION OF VOLTAGE-GATED ION CHANNELS

被引：156

作者：

CATTERALL, WA

机构：

[1] Dept of Pharmacology, SJ-30 University of Washington, Seattle

来源：

TRENDS IN NEUROSCIENCES | 1993年 / 16卷 / 12期

关键词：

D O I：

10.1016/0166-2236(93)90193-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The principal subunits of the voltage-gated Na+, Ca2+ and K+ channels are members of a related gene family and are functionally autonomous in voltage-dependent activation, ion conductance and inactivation. In this article, recent work locating the structural elements that are responsible for these three basic functions of the voltage-gated ion channels is reviewed. These studies reveal strong functional analogies among the different ion channels and suggest that the striking differences in their properties arise as variations on a common structural and functional theme.

引用

页码：500 / 506

页数：7

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