A RANDOMIZED STUDY OF INTRAVESICAL MITOMYCIN-C, BACILLUS-CALMETTE-GUERIN TICE AND BACILLUS-CALMETTE-GUERIN RIVM TREATMENT IN PTA-PT1 PAPILLARY CARCINOMA AND CARCINOMA IN-SITU OF THE BLADDER

被引:100
作者
VEGT, PDJ
WITJES, JA
WITJES, WPJ
DOESBURG, WH
DEBRUYNE, FMJ
VANDERMEIJDEN, APM
机构
[1] BOSCH MED CTR,SHERTOGENBOSCH,NETHERLANDS
[2] UNIV NIJMEGEN HOSP,DEPT UROL,6500 HB NIJMEGEN,NETHERLANDS
[3] UNIV NIJMEGEN HOSP,DEPT MED STAT,6500 HB NIJMEGEN,NETHERLANDS
关键词
BLADDER NEOPLASMS; DRUG THERAPY; IMMUNOTHERAPY; BCG VACCINE;
D O I
10.1016/S0022-5347(01)67606-7
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Results of a randomized prospective study are reported in which mitomycin C, Tice bacillus Calmette-Guerin (BCG) and RIVM-BCG were compared in 437 patients with primary or recurrent pTa and pT1 bladder tumors, including carcinoma in situ. The followup (or time in study) varied from 2 to 81 months (mean 36 months). After complete transurethral resection of all visible tumors the patients were treated with 30 mg. mitomycin C once a week for 4 consecutive weeks and thereafter every month for a total of 6 months, and 5 x 10(8) colony-forming units Tice BCG or RIVM-BCG once a week for 6 consecutive weeks. For papillary tumors mitomycin C and RIVM-BCG treatments were equally effective (p = 0.53), and mitomycin C was more effective than Tice BCG therapy (p = 0.01).
引用
收藏
页码:929 / 933
页数:5
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