RENAL NERVE ACTIVITY DOES NOT CONTRIBUTE TO THE DEVELOPMENT OF RENOVASCULAR HYPERTENSION IN RATS WITH ABDOMINAL AORTIC CONSTRICTION

被引：10

作者：

EKLOF, AC ^{[1
]}

HOKFELT, T ^{[1
]}

APERIA, A ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT HISTOL,S-10401 STOCKHOLM 60,SWEDEN

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 1991年 / 141卷 / 01期

关键词：

ANGIOTENSIN-II; NA EXCRETION; RENAL DENERVATION; RENOVASCULAR HYPERTENSION;

D O I：

10.1111/j.1748-1716.1991.tb09046.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

This study examines the influence of renal nerves on the development of renovascular hypertension in proximal aortic constricted rats. The rats were studied 1 week after unilateral or bilateral denervation of the renal artery. Denervation had no effect on the increase in mean arterial pressure induced by the constriction. The glomerular filtration rate and filtration fraction in control and in proximal aortic constricted rats were not influenced by the denervation. The Na excretion was increased in the denervated kidney both in control and in proximal aortic constricted rats. Plasma angiotensin II levels were not different from controls in innervated or unilaterally denervated proximal aoritic constricted rats. In bilaterally denervated proximal aortic constricted rats the plasma angiotensin II levels were significantly higher. The renovascular hypertension and the alternation in renal function in proximal aortic constricted rats are not dependent on renal nerve activity.

引用

页码：71 / 77

页数：7

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