(2S,3S)-DICYCLOHEXYL TARTRATE AS MOBILE PHASE ADDITIVE FOR THE DETERMINATION OF THE ENANTIOMERIC PURITY OF (S)-ATROPINE IN TABLETS

被引：14

作者：

HELDIN, E

HUYNH, NH

PETTERSSON, C

机构：

[1] Department of Analytical Pharmaceutical Chemistry, Biomedical Centre, Uppsala University, S-751 23 Uppsala

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 592卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(92)85105-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A chromatographic method for the determination of the enantiomeric purity of (S)-atropine is presented and has been applied to the analysis of tablets. The (2S,3S)-enantiomer of the chiral selector, dicyclohexyl tartrate, was used as selector in order to elute the impurity, (R)-atropine, before the main component, (S)-atropine.

引用

页码：339 / 343

页数：5

共 7 条

[1] SEPARATION OF OPTICAL ISOMERS OF SCOPOLAMINE, COCAINE, HOMATROPINE, AND ATROPINE [J].