HYPOURICEMIC EFFECT OF ZUCLOPENTHIXOL - A POTENTIAL MARKER OF DRUG COMPLIANCE

被引：9

作者：

BLOCH, M ^{[1
]}

GUR, E ^{[1
]}

SHALEV, AY ^{[1
]}

机构：

[1] HADASSAH UNIV HOSP, DEPT PSYCHIAT, POB 12000, IL-91120 JERUSALEM, ISRAEL

来源：

PSYCHOPHARMACOLOGY | 1992年 / 109卷 / 03期

关键词：

ZUCLOPENTHIXOL; NEUROLEPTICS; SIDE-EFFECTS; URIC ACID; URICOSURIC AGENTS; NONCOMPLIANCE;

D O I：

10.1007/BF02245887

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Twelve newly-admitted psychotic patients were treated with clinical doses of zuclopenthixol (ZPT). Plasma uric acid (PUA) was measured before and during treatment. ZPT reduced PUA in all the patients by an average of 29.6 % (P < 0.0001). PUA levels during treatment correlated with those obtained before treatment (R = 0.871, P < 0.0002). PUA returned to initial levels on discontinuation of treatment. Uric acid excretion increased during treatment. It is concluded that ZPT is a potent uricosuric agent, capable of producing persistent hypouricemia while administered. Such hypouricemia might be a useful indicator of drug compliance.

引用

页码：377 / 378

页数：2

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