AN IMPROVED THIOFLAVINE-S METHOD FOR STAINING NEUROFIBRILLARY TANGLES AND SENILE PLAQUES IN ALZHEIMERS-DISEASE

被引：116

作者：

GUNTERN, R ^{[1
]}

BOURAS, C ^{[1
]}

HOF, PR ^{[1
]}

VALLET, PG ^{[1
]}

机构：

[1] CUNY MT SINAI SCH MED,FISHBERG RES CTR,NEW YORK,NY 10029

来源：

EXPERIENTIA | 1992年 / 48卷 / 01期

关键词：

SENILE PLAQUES; NEUROFIBRILLARY TANGLES; ALZHEIMERS DISEASE; THIOFLAVINE-S;

D O I：

10.1007/BF01923594

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Large differences are usually observed when standard staining methods for a number of pathological lesions in neurodegenerative disorders are compared. With the modified thioflavine S method presented here (easy and cheap to perform), the morphological appearance of the stained neurofibrillary tangles (NFT) and senile plaques (SP) is greatly improved. Furthermore, the intense contrast between stained lesions and background obtained with this technique permits an accurate automatic quantification of NFT and SP using a computer-assisted image analysis system.

引用

页码：8 / 10

页数：3

共 18 条

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