Determination of competitive adsorption isotherms of enantiomers on a dual-site adsorbent

被引：18

作者：

Lim, BG ^{[1
]}

Ching, CB ^{[1
]}

Tan, RBH ^{[1
]}

机构：

[1] NATL UNIV SINGAPORE,DEPT CHEM ENGN,SINGAPORE 0511,SINGAPORE

来源：

SEPARATIONS TECHNOLOGY | 1995年 / 5卷 / 04期

关键词：

praziquantel; adsorption isotherm; microcrystalline cellulose triacetate; concentration pulse chromatography;

D O I：

10.1016/0956-9618(95)00126-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The competitive adsorption isotherms of praziquantel enantiomers on microcrystalline cellulose triacetate were determined by concentration pulse chromatography. A model comprising a non-selective linear term and a selective first order improved Langmuir term was found to fit the data excellently. It is postulated that this chiral stationary phase consists of two types of binding sites: one responsible for the chiral, selective interactions and one responsible for the achiral, non-selective interactions of the enantiomers with the stationary phase. The selective sites are easily saturated compared to the non-selective sites, accounting for the experimental observation of lower separation efficiency at higher enantiomer concentrations.

引用

页码：213 / 228

页数：16

共 37 条

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