2ND MESSENGERS IN THE COCHLEA

被引：6

作者：

COLING, DE ^{[1
]}

SCHACHT, J ^{[1
]}

机构：

[1] UNIV MICHIGAN, KRESGE HEARING RES INST, ANN ARBOR, MI 48109 USA

来源：

ACTA OTO-LARYNGOLOGICA | 1995年 / 115卷 / 02期

关键词：

COCHLEA; 2ND MESSENGERS; CAMP; CGMP; DIACYLGLYCERIDES; INOSITOL 1,4,5-TRISPHOSPHATE; CALCIUM; CALMODULIN; SIGNAL TRANSDUCTION; HOMEOSTASIS; HAIR CELLS; STRIA VASCULARIS;

D O I：

10.3109/00016489509139295

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Second messengers are vital to the regulation of nearly every aspect of cellular physiology. Evidence is reviewed for the role of second messengers in cochlear fluid homeostasis, hair cell adaptation, motility and synaptic activity. We suggest that the elucidation of the role of second messengers in the regulation of cochlear physiology will be important for the therapeutic management of otopathologies and the side effects of ototoxic agents.

引用

页码：218 / 221

页数：4

共 25 条

[1]

AHLSTROM P, 1975, LARYNGOSCOPE, V85, P1241, DOI 10.1288/00005537-197507000-00016

[2] ADENYLATE-CYCLASE ACTIVITY IN THE FETAL AND THE EARLY POSTNATAL INNER-EAR OF THE MOUSE [J].

ANNIKO, M ;

SPANGBERG, ML ;

SCHACHT, J .

HEARING RESEARCH, 1981, 4 (01) :11-22

[3] EVOKED MECHANICAL RESPONSES OF ISOLATED COCHLEAR OUTER HAIR-CELLS [J].

BROWNELL, WE ;

BADER, CR ;

BERTRAND, D ;

DERIBAUPIERRE, Y .

SCIENCE, 1985, 227 (4683) :194-196

[4] PROTEIN-PHOSPHORYLATION IN THE ORGAN OF CORTI - DIFFERENTIAL REGULATION BY 2ND MESSENGERS BETWEEN BASE AND APEX [J].

COLING, DE ;

SCHACHT, J .

HEARING RESEARCH, 1991, 57 (01) :113-120

[5]

DAWSON VL, 1993, J NEUROSCI, V13, P2651

[6]

DOI K, 1992, ACTA OTO-LARYNGOL, V112, P667, DOI 10.3109/00016489209137457

[7]

DULON D, 1990, J NEUROSCI, V10, P1388

[8]

EATOCK RA, 1987, J NEUROSCI, V7, P2821

[9] MECHANISMS OF MOVEMENT IN OUTER HAIR-CELLS AND A POSSIBLE STRUCTURAL BASIS [J].

FLOCK, A ;

FLOCK, B ;

ULFENDAHL, M .

ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 1986, 243 (02) :83-90

[10] GUANYLATE CYCLASE AND CYCLIC GUANOSINE MONOPHOSPHATE IN GUINEA-PIG COCHLEA [J].

GUTH, PS ;

STOCKWELL, M .

JOURNAL OF NEUROCHEMISTRY, 1977, 28 (01) :263-265

← 1 2 3 →