INTERFERON-ALPHA HYBRIDS

被引：16

作者：

HORISBERGER, MA

DIMARCO, S

机构：

[1] Core Drug Discovery Technology, Pharmaceutical Research Department, Ciba-Geigy Limited

来源：

PHARMACOLOGY & THERAPEUTICS | 1995年 / 66卷 / 03期

关键词：

IFN-ALPHA; IFN-ALPHA RECEPTOR; IFN HYBRID; STRUCTURAL AND HOMOLOGY MODELS;

D O I：

10.1016/0163-7258(95)00008-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The alpha-interferons (IFN-alpha) belong to a family of polypeptides comprising several subtypes. Using recombinant DNA technology, it has been possible to create IFN hybrids that provide novel combinations of the amino acid residues from the parental protein sequences. They have been used to study structure-activity relationships of IFN-alpha and interactions with the IFN-alpha receptor, and to create analogs of natural IFNs with novel properties for potential therapeutic application. The biological data obtained with these hybrids are now evaluated in terms of the published structural and homology models of IFN-beta and -alpha.

引用

页码：507 / 534

页数：28

共 138 条

[1] 3-DIMENSIONAL STRUCTURE OF A GENETICALLY ENGINEERED VARIANT OF PORCINE GROWTH-HORMONE [J].