Neurotrophic Factors for Retinal Ganglion Cell Neuropathy - With a Special Reference to Diabetic Neuropathy in the Retina

被引：54

作者：

Bikbova, Guzel ^{[1
]}

Oshitari, Toshiyuki ^{[1
]}

Baba, Takayuki ^{[1
]}

Yamamoto, Shuichi ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Ophthalmol & Visual Sci, Chuo Ku, Inohana 1-8-1, Chiba, Chiba 2608670, Japan

来源：

CURRENT DIABETES REVIEWS | 2014年 / 10卷 / 03期

关键词：

Neurotrophic factor; retinal ganglion cell neuropathy; diabetes; neuroprotection;

D O I：

10.2174/1573399810666140508121927

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Diabetes mellitus is a disease with a devastating impact on population. Recent data revealed that early retinal neuropathy in patients with diabetic retinopathy involved a reduced expression of brain-derived neurotrophic factor. Retinal ganglion cells (RGC) neuropathy is a progressive optic nerve neuropathy with RGC death and axonal degeneration, and it leads to blindness in the elderly population worldwide. Thus, neuroprotective therapies that rescue damaged RGCs and inhibit the progression of RGC loss and axonal degeneration are needed. This review introduces potential neuroprotective therapies using different neurotrophic factors for damaged RGC in eyes with RGC neuropathy associated diseases.

引用

页码：166 / 176

页数：11

共 165 条

[1]

Cytidine 5′-diphosphocholine (CDP-choline) in stroke and other CNS disorders [J].