HOW BIG IS THE UNIVERSE OF EXONS

被引：201

作者：

DORIT, RL

SCHOENBACH, L

GILBERT, W

机构：

[1] Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138

来源：

SCIENCE | 1990年 / 250卷 / 4986期

关键词：

D O I：

10.1126/science.2255907

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

If genes have been assembled from exon subunits, the frequency with which exons are reused leads to an estimate of the size of the underlying exon universe. An exon database was constructed from available protein sequences, and homologous exons were identified on the basis of amino acid identity; statistically significant matches were determined by Monte Carlo methods. It is estimated that only 1000 to 7000 exons were needed to construct all proteins.

引用

页码：1377 / 1382

页数：6

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