CYANIDE INDUCES CA2+-DEPENDENT AND CA2+-INDEPENDENT RELEASE OF GLUTAMATE FROM MOUSE-BRAIN SLICES

被引：43

作者：

PATEL, MN ^{[1
]}

ARDELT, BK ^{[1
]}

YIM, GKW ^{[1
]}

ISOM, GE ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT PHARMACOL & TOXICOL,W LAFAYETTE,IN 47907

来源：

NEUROSCIENCE LETTERS | 1991年 / 131卷 / 01期

关键词：

HISTOTOXIC-HYPOXIA; GLUTAMATE RELEASE; CYANIDE; BRAIN SLICE;

D O I：

10.1016/0304-3940(91)90332-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of cyanide-induced histotoxic hypoxia on endogenous glutamate release from mouse cortical, cerebellar and hippocampal slices was studied. Incubation of slices with cyanide over a 30 min period resulted in extracellular accumulation of glutamate which was decreased in the absence of Ca2+ in the incubation media. When glutamate release was continuously monitored by fluorometry, cyanide initiated a rapid release of glutamate. This initital release was found to be independent of extracellular calcium. Depolarizing concentrations of potassium chloride produced a predominantly Ca2+-dependent release. It is concluded that cyanide exposure induced a rapid release of endogenous glutamate mediated by both Ca2+-dependent and Ca2+-independent mechanisms.

引用

页码：42 / 44

页数：3

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