PREDICTIVE B-CELL AND T-CELL LINEAR EPITOPES IN STRUCTURAL PROTEINS OF HTLV-I, HTLV-II, AND STLV-I

被引:15
作者
LAL, RB
GRIFFIS, KP
机构
[1] Retrovirus Diseases Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta
关键词
D O I
10.1089/aid.1991.7.663
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The primary amino acid sequences derived from the gag, pol, and env gene products of human T-cell lymphotropic virus type I (HTLV-I) and type II (HTLV-II) and the env protein of simian T-cell lymphotropic virus type I (STLV-I) were aligned and computer algorithms were used to predict B- and T-cell epitopes. Structural B- and T-cell motifs that showed amino acid sequence conservation of antigenic determinants in HTLV-I, HTLV-II, and STLV-I, as well as different antigenic determinants of HTLV-I and HTLV-II, were identified. Several of these B and T epitopes have been shown experimentally to be immunodominant and two of the B epitopes have been used for type-specific serology. These predictive epitopes provide a guide to develop improved diagnostic assays and for the development of potential subunit vaccines for HILV-I and HTLV-II.
引用
收藏
页码:663 / 670
页数:8
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