SULFONIC-ACID POLYMERS AS A NEW CLASS OF HUMAN-IMMUNODEFICIENCY-VIRUS INHIBITORS

被引：63

作者：

MOHAN, P

SCHOLS, D

BABA, M

DECLERCQ, E

机构：

[1] FUKUSHIMA MED SCH, DEPT MICROBIOL, FUKUSHIMA 960, JAPAN

[2] KATHOLIEKE UNIV LEUVEN, REGA INST MED RES, LOUVAIN, BELGIUM

来源：

ANTIVIRAL RESEARCH | 1992年 / 18卷 / 02期

关键词：

SULFONIC ACID POLYMER; HUMAN IMMUNODEFICIENCY VIRUS; GLYCOPROTEIN-GP120; CD4-RECEPTOR; SYNCYTIUM FORMATION;

D O I：

10.1016/0166-3542(92)90034-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Four sulfonic acid polymers [poly(4-styrenesulfonic acid)(PSS), poly(anetholesulfonic acid)(PAS), poly(vinylsulfonic acid)(PVS), poly(2-acrylamido-2-methyl-1-propanesulfonic acid)(PAMPS)] have been found to inhibit the cytopathicity of HIV-1 and HIV-2 in MT-4 cells at concentrations that are not toxic to the host cells. The sulfonic acid polymers also inhibited syncytium formation in co-cultures of MOLT-4 cells with HIV-1- or HIV-2-infected HUT-78 cells. They also inhibited binding of anti-gp120 mAb to HIV-1 gp120 and blocked adsorption of HIV-1 virions to MT-4 cells. PSS and PAS, but not PVS and PAMPS, interfered with the binding of OKT4A/Leu3a to the CD4 receptor. The anti-HIV activity of these polyanionic compounds can be ascribed to inhibition of the gp120-CD4 interaction. Sulfonic acid polymers represent a lead of anti-HIV compounds that warrant further evaluation of their therapeutic potential.

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页码：139 / 150

页数：12

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