VACCINATION OF CATTLE WITH THE N-TERMINUS OF L2 IS NECESSARY AND SUFFICIENT FOR PREVENTING INFECTION BY BOVINE PAPILLOMAVIRUS-4

被引：81

作者：

CHANDRACHUD, LM

GRINDLAY, GJ

MCGARVIE, GM

ONEIL, BW

WAGNER, ER

JARRETT, WFH

CAMPO, MS

机构：

[1] BEATSON INST CANC RES, CRC, BEATSON LABS, GLASGOW G61 1BD, LANARK, SCOTLAND

[2] UNIV GLASGOW, DEPT VET PATHOL, GLASGOW G61 1QH, LANARK, SCOTLAND

来源：

VIROLOGY | 1995年 / 211卷 / 01期

关键词：

D O I：

10.1006/viro.1995.1392

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have previously shown that cattle vaccinated with L2, the minor structural protein of bovine papillomavirus-4 (BPV4), do not develop alimenlary papillomas upon challenge with BPV-4. Analysis of the B and T cell response in L2-vaccinated animals showed that the majority of the response was directed against the N-terminus and C-terminus of L2 with little response against the middle portion. Cattle were vaccinated with the N-terminus or the C-terminus of L2. The animals vaccinated with the N-terminus were completely protected from viral challenge, whereas the animals vaccinated with the C-terminus were not. Further analysis with synthetic overlapping peptides spanning the entire N-terminus mapped a B cell immunodominant epitope at amino acid 101-120. This epitope was recognised by all vaccinated animals. (C) 1995 Academic Press, Inc.

引用

页码：204 / 208

页数：5

共 17 条

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