LEUKEMIA INHIBITORY FACTOR PROMOTES THE NEURONAL DEVELOPMENT OF SPINAL-CORD PRECURSORS FROM THE NEURAL-TUBE

被引:50
作者
RICHARDS, LJ [1 ]
KILPATRICK, TJ [1 ]
BARTLETT, PF [1 ]
MURPHY, M [1 ]
机构
[1] ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,PARKVILLE,VIC 3050,AUSTRALIA
关键词
SPINAL CORD DEVELOPMENT; LIF; NEURONS; NEURONAL DIFFERENTIATION; GROWTH FACTORS;
D O I
10.1002/jnr.490330314
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent evidence from our laboratory has shown that leukemia inhibitory factor (LIF) can act early in peripheral nervous system development. We have investigated a potential role of LIF in the developing spinal cord. In explants and dissociated cultures of spinal cord primordium, LIF stimulated a profuse neurite outgrowth. To determine if these effects were related to neuronal differentiation, cells were plated at low cell density and stained for neurofilament. LIF stimulated an increase in the number of newly differentiated neurons, without inducing proliferation of the precursors. Given that LIF has previously reported effects as a cholinergic switching factor for sympathetic neurons, we investigated whether LIF had similar effects in these spinal cord cultures. LIF increased the number of cholinergic neurons in proportion to its overall effect on the stimulation of all neurofilament positive neurons in the culture. These data show that LIF stimulates the generation of spinal cord neurons from their precursors and further implicates a role for LIF in nervous system development.
引用
收藏
页码:476 / 484
页数:9
相关论文
共 33 条
[1]   DIFFERENTIATION-INDUCING FACTOR PURIFIED FROM CONDITIONED MEDIUM OF MITOGEN-TREATED SPLEEN-CELL CULTURES STIMULATES BONE-RESORPTION [J].
ABE, E ;
TANAKA, H ;
ISHIMI, Y ;
MIYAURA, C ;
HAYASHI, T ;
NAGASAWA, H ;
TOMIDA, M ;
YAMAGUCHI, Y ;
HOZUMI, M ;
SUDA, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (16) :5958-5962
[2]   EGF AND TGF-ALPHA STIMULATE RETINAL NEUROEPITHELIAL CELL-PROLIFERATION INVITRO [J].
ANCHAN, RM ;
REH, TA ;
ANGELLO, J ;
BALLIET, A ;
WALKER, M .
NEURON, 1991, 6 (06) :923-936
[3]  
BAUMANN H, 1989, J IMMUNOL, V143, P1163
[4]   MOTONEURONS PURIFIED BY CELL SORTING RESPOND TO 2 DISTINCT ACTIVITIES IN MYOTUBE-CONDITIONED MEDIUM [J].
CALOF, AL ;
REICHARDT, LF .
DEVELOPMENTAL BIOLOGY, 1984, 106 (01) :194-210
[5]  
COCHARD P, 1984, J NEUROSCI, V4, P2080
[6]   MUSCLE-DERIVED FACTORS THAT SUPPORT SURVIVAL AND PROMOTE FIBER OUTGROWTH FROM EMBRYONIC CHICK SPINAL MOTOR NEURONS IN CULTURE [J].
DOHRMANN, U ;
EDGAR, D ;
SENDTNER, M ;
THOENEN, H .
DEVELOPMENTAL BIOLOGY, 1986, 118 (01) :209-221
[7]   FIBROBLAST GROWTH FACTOR-MEDIATED PROLIFERATION OF CENTRAL-NERVOUS-SYSTEM PRECURSORS DEPENDS ON ENDOGENOUS PRODUCTION OF INSULIN-LIKE GROWTH FACTOR-I [J].
DRAGO, J ;
MURPHY, M ;
CARROLL, SM ;
HARVEY, RP ;
BARTLETT, PF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) :2199-2203
[8]   A METHOD FOR THE ISOLATION OF PURIFIED MURINE NEUROEPITHELIAL CELLS FROM THE DEVELOPING MOUSE-BRAIN [J].
DRAGO, J ;
MURPHY, M ;
BAILEY, KA ;
BARTLETT, PF .
JOURNAL OF NEUROSCIENCE METHODS, 1991, 37 (03) :251-256
[9]   MOLECULAR-CLONING AND EXPRESSION OF CDNA-ENCODING A MURINE MYELOID-LEUKEMIA INHIBITORY FACTOR (LIF) [J].
GEARING, DP ;
GOUGH, NM ;
KING, JA ;
HILTON, DJ ;
NICOLA, NA ;
SIMPSON, RJ ;
NICE, EC ;
KELSO, A ;
METCALF, D .
EMBO JOURNAL, 1987, 6 (13) :3995-4002
[10]  
GIESS MC, 1984, J NEUROSCI, V4, P1442