VALPROIC ACID PHARMACOKINETICS IN THE MOUSE FOLLOWING CONTROLLED-RELEASE OF PHARMACOLOGIC AND TOXIC DOSES VIA NOVEL IMPLANTABLE AND REFILLABLE DRUG RESERVOIRS

被引：7

作者：

NAU, H

FINLEY, P

WILLIAMS, J

BRENDEL, K

机构：

[1] UNIV ARIZONA,HLTH SCI CTR,DEPT PATHOL,TUCSON,AZ 85724

[2] UNIV ARIZONA,HLTH SCI CTR,DEPT PHARMACOL,TUCSON,AZ 85724

来源：

BIOPHARMACEUTICS & DRUG DISPOSITION | 1983年 / 4卷 / 02期

关键词：

D O I：

10.1002/bdd.2510040209

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：173 / 182

页数：10

共 10 条

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BRENDEL K, UNPUB

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[3]

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[4]

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[5]

NAU H, 1982, J PHARMACOL EXP THER, V220, P654

[6] PHARMACOKINETICS OF VALPROIC ACID AND METABOLITES IN MOUSE PLASMA AND BRAIN FOLLOWING CONSTANT-RATE APPLICATION OF THE DRUG AND ITS UNSATURATED METABOLITE WITH AN OSMOTIC DELIVERY SYSTEM [J].

NAU, H ;

ZIERER, R .

BIOPHARMACEUTICS & DRUG DISPOSITION, 1982, 3 (04) :317-328

[7] A NEW MODEL FOR EMBRYOTOXICITY TESTING - TERATOGENICITY AND PHARMACOKINETICS OF VALPROIC ACID FOLLOWING CONSTANT-RATE ADMINISTRATION IN THE MOUSE USING HUMAN THERAPEUTIC DRUG AND METABOLITE CONCENTRATIONS [J].

NAU, H ;

ZIERER, R ;

SPIELMANN, H ;

NEUBERT, D ;

GANSAU, C .

LIFE SCIENCES, 1981, 29 (26) :2803-2813

[8]

NAU H, UNPUB

[9] EMBRYONIC-DEVELOPMENT AND MITOCHONDRIAL-FUNCTION .1. EFFECTS OF CHLORAMPHENICOL INFUSION ON SYNTHESIS OF CYTOCHROME-OXIDASE AND DNA IN RAT EMBRYOS DURING LATE ORGANOGENESIS [J].

OERTER, D ;

BASS, R .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1975, 290 (2-3) :175-189

[10] RATE-CONTROLLED DRUG-DOSAGE [J].

URQUHART, J .

DRUGS, 1982, 23 (03) :207-226

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