GLOBAL MINIMUM ENERGY CONFORMATIONS OF THYROTROPIN-RELEASING-HORMONE ANALOGS BY SIMULATED ANNEALING .2.

被引：4

作者：

GARDUNOJUAREZ, R ^{[1
]}

PEREZNERI, F ^{[1
]}

机构：

[1] UNIV AUTONOMA EDO MORELOS,FAC CIENCIAS QUIM & IND,CUERNAVACA,MORELOS,MEXICO

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 1991年 / 8卷 / 04期

关键词：

D O I：

10.1080/07391102.1991.10507842

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lowest contormational energy structures of seventeen thyrotropin releasing hormone analogs have been studied by simulated annealing. A surprising conformational similarity was observed for the peptide backbone. The possible role of each substituent in its biological activity is inferred. A composite hydrogen-bonding environment is proposed for the TRH with respect to receptor binding.

引用

页码：737 / 758

页数：22

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