ALUMINUM(III) FACILITATES THE OXIDATION OF NADH BY THE SUPEROXIDE ANION

被引：70

作者：

KONG, S ^{[1
]}

LIOCHEV, S ^{[1
]}

FRIDOVICH, I ^{[1
]}

机构：

[1] DUKE UNIV, MED CTR, MED CTR, POB 3711, DURHAM, NC 27710 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1992年 / 13卷 / 01期

基金：

美国国家科学基金会;

关键词：

ALUMINUM AND NADH OXIDATION; SUPEROXIDE AND NADH OXIDATION; FREE RADICALS;

D O I：

10.1016/0891-5849(92)90168-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Al(III) augments the oxidation of reduced nicotinamide adenine dinucleotide (NADH) by enzymatic or photochemical sources of O2-. Superoxide dismutase, but not catalase, inhibited this action of Al(III). It thus appears that Al(III) forms a complex with O2-, which is a stronger oxidant than is O2- itself and which may contribute to the adverse biological effects of Al(III).

引用

页码：79 / 81

页数：3

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