ONCOGENES IN X-RAY-TRANSFORMED C3H 10T1/2 MOUSE CELLS AND IN X-RAY-INDUCED MOUSE FIBROSARCOMA (RIF-1) CELLS

被引:8
作者
LEUTHAUSER, SWC
THOMAS, JE
GUERNSEY, DL
机构
[1] DALHOUSIE UNIV,FAC MED,DEPT PATHOL,SIR CHARLES TUPPER MED BLDG,HALIFAX B3H 4H7,NS,CANADA
[2] DALHOUSIE UNIV,FAC MED,DEPT PHYSIOL & BIOPHYS,HALIFAX B3H 4H7,NS,CANADA
[3] USA,HLTH CLIN,ROCK ISL,IL 61299
[4] UNIV PENN,SCH MED,HOWARD HUGHES MED INST,DEPT MICROBIOL,PHILADELPHIA,PA 19104
关键词
D O I
10.1080/09553009214551811
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In order to better understand the molecular basis of X-ray induced carcinogenesis we have investigated RNA levels of oncogenes in an X-ray transformed C3H 10T1/2 fibroblast line (XTD) and RIF-I cells isolated from an X-ray-induced fibrosarcoma in a C3H mouse. Steady-state levels of K-ras, H-ras, N-ras, abl, sis, src, and fos were unchanged in the X-ray-transformed cells compared with non-transformed C3H 10T1/2 cells. However, myc and raf mRNA levels were increased dramatically in thc transformed cells. Data further suggests a possible alteration in processing of raf RNA in the XTD cells. Southern blot analysis of secondary transfectants induced with XTD DNA indicated that the oncogenic phenotype did not segregate with the myc or raf loci; nor with nine other oncogenes analysed.
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页码:45 / 51
页数:7
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