EXPRESSION OF 11-BETA-OHSD ALONG THE NEPHRON OF MAMMALS AND HUMANS

被引：34

作者：

KENOUCH, S

ALFAIDY, N

BONVALET, JP

FARMAN, N

机构：

[1] INSERM U246, UER Xavier Bichat, Paris

来源：

STEROIDS | 1994年 / 59卷 / 02期

关键词：

RENAL TUBULE; MINERALOCORTICOID RECEPTORS; ALDOSTERONE; GLUCOCORTICOID; REDUCTASE;

D O I：

10.1016/0039-128X(94)90084-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) plays a major role in the protection of the mineralocorticoid receptor (MR). This cellular mechanism of aldosterone selectivity relies on the coexpression of MR and 11 beta-OHSD in the same cells. Localization of renal 11 beta-OHSD along the nephron is reviewed; comparison of data contained in different species is made; and original data is presented to show that the catalytic activity of the enzyme in tubules from human kidney, is the highest in the mineralocorticoid-sensitive distal nephron.

引用

页码：100 / 104

页数：5

共 18 条

[1]

AGARWAL AK, 1989, J BIOL CHEM, V264, P18939

[2] HISTOCHEMICAL DISTRIBUTION OF HYDROXYSTEROID DEHYDROGENASES IN KIDNEY AND LIVER [J].