ANTIINFLAMMATORY ACTIVITY OF GALLIC ACID

被引：351

作者：

KROES, BH ^{[1
]}

VANDENBERG, AJJ ^{[1
]}

VANUFFORD, HCQ ^{[1
]}

VANDIJK, H ^{[1
]}

LABADIE, RP ^{[1
]}

机构：

[1] UNIV UTRECHT, FAC MED, MICROBIOL LAB, EXPTL IMMUNOL SECT, 3508 TB UTRECHT, NETHERLANDS

来源：

PLANTA MEDICA | 1992年 / 58卷 / 06期

关键词：

GALLIC ACID; ANTIINFLAMMATORY ACTIVITY; GRANULOCYTES; IMMUNOMODULATION; CHEMILUMINESCENCE;

D O I：

10.1055/s-2006-961535

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Gallic acid was found to possess anti-inflammatory activity towards zymosan-induced acute food pad swelling in mice. In vitro studies on the mode of action of gallic acid revealed that this compound interferes with the functioning of polymorphonuclear leukocytes (PMNs). Scavenging of superoxide anions, inhibition of myeloperoxidase release and activity as well as a possible interference with the assembly of active NADPH-oxidase may account for the inhibition of inflammatory process by gallic acid. Structure-activity relationship analysis showed that the o-dihydroxy group of gallic acid is important for the inhibitory activity in vitro.

引用

页码：499 / 504

页数：6

共 36 条

[1] ANIANSSON H, 1984, ACTA PATH MICRO IM C, V92, P357
[2] [Anonymous], IMMUNOLOGY
[3] THE SUPEROXIDE-FORMING ENZYMATIC SYSTEM OF PHAGOCYTES
BELLAVITE, P
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 1988, 4 (04) : 225 - 261
[4] ANTI-INFLAMMATORY EFFECTS OF FREE-RADICAL SCAVENGERS AND ANTIOXIDANTS - FURTHER SUPPORT FOR PROINFLAMMATORY ROLES OF ENDOGENOUS HYDROGEN-PEROXIDE AND LIPID PEROXIDES
BRAGT, PC
BANSBERG, JI
BONTA, IL
[J]. INFLAMMATION, 1980, 4 (03) : 289 - 299
[5] CHRISTOW S, 1991, PHARMAZIE, V46, P282
[6] DECHATELET LR, 1982, J IMMUNOL, V129, P1589
[7] METABOLIC-ACTIVATION OF 1-NAPHTHOL AND PHENOL BY A SIMPLE SUPEROXIDE-GENERATING SYSTEM AND HUMAN-LEUKOCYTES
EASTMOND, DA
FRENCH, RC
ROSS, D
SMITH, MT
[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1987, 63 (01) : 47 - 62
[8] EDWARDS SW, 1987, J CLIN LAB IMMUNOL, V22, P35
[9] FANTONE JC, 1985, CURRENT CONCEPTS OXY, P27
[10] FLOWER RJ, 1974, PHARMACOL RES COMMUN, V26, P33

← 1 2 3 4 →