ANTIINFLAMMATORY ACTIVITY OF GALLIC ACID

被引:351
作者
KROES, BH [1 ]
VANDENBERG, AJJ [1 ]
VANUFFORD, HCQ [1 ]
VANDIJK, H [1 ]
LABADIE, RP [1 ]
机构
[1] UNIV UTRECHT, FAC MED, MICROBIOL LAB, EXPTL IMMUNOL SECT, 3508 TB UTRECHT, NETHERLANDS
关键词
GALLIC ACID; ANTIINFLAMMATORY ACTIVITY; GRANULOCYTES; IMMUNOMODULATION; CHEMILUMINESCENCE;
D O I
10.1055/s-2006-961535
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Gallic acid was found to possess anti-inflammatory activity towards zymosan-induced acute food pad swelling in mice. In vitro studies on the mode of action of gallic acid revealed that this compound interferes with the functioning of polymorphonuclear leukocytes (PMNs). Scavenging of superoxide anions, inhibition of myeloperoxidase release and activity as well as a possible interference with the assembly of active NADPH-oxidase may account for the inhibition of inflammatory process by gallic acid. Structure-activity relationship analysis showed that the o-dihydroxy group of gallic acid is important for the inhibitory activity in vitro.
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页码:499 / 504
页数:6
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