THE TINS TIPS LECTURE - THE MOLECULAR-BIOLOGY OF MAMMALIAN GLUTAMATE-RECEPTOR CHANNELS

被引：832

作者：

SEEBURG, PH

机构：

[1] University of Heidelberg, Centre of Molecular Biology (ZMBH), Laboratory of Molecular Neuroendocrinology, 69052 Heidelberg, PO Box 10 62 49

来源：

TRENDS IN NEUROSCIENCES | 1993年 / 16卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0166-2236(93)90093-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In native brain membranes the principal excitatory neurotransmitter L-glutamate activates cation-conducting channels with distinct biophysical and pharmacological properties. Molecular cloning has revealed the existence of 16 channel subunits that can assemble in homomeric or heteromeric configurations in vitro to form receptor channels with disparate functional properties. This review describes the different channel types obtained by recombinant means and the genetic mechanisms controlling the expression of functionally important channel structures.

引用

页码：359 / 365

页数：7

共 75 条

[71] STRUCTURE-ACTIVITY-RELATIONSHIPS IN THE DEVELOPMENT OF EXCITATORY AMINO-ACID RECEPTOR AGONISTS AND COMPETITIVE ANTAGONISTS [J].

WATKINS, JC ;

KROGSGAARDLARSEN, P ;

HONORE, T .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (01) :25-33

[72] CLONING OF A PUTATIVE HIGH-AFFINITY KAINATE RECEPTOR EXPRESSED PREDOMINANTLY IN HIPPOCAMPAL CA3 CELLS [J].

WERNER, P ;

VOIGT, M ;

KEINANEN, K ;

WISDEN, W ;

SEEBURG, PH .

NATURE, 1991, 351 (6329) :742-744

[73]

Wisden W, 1993, Curr Opin Neurobiol, V3, P291, DOI 10.1016/0959-4388(93)90120-N

[74]

WISDEN W, IN PRESS J NEUROSCI

[75] MOLECULAR-CLONING OF A CDNA-ENCODING A NOVEL MEMBER OF THE MOUSE GLUTAMATE RECEPTOR CHANNEL FAMILY [J].

YAMAZAKI, M ;

ARAKI, K ;

SHIBATA, A ;

MISHINA, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 183 (02) :886-892

← 1 2 3 4 5 6 7 8 →