LEU-7 IMMUNOREACTIVITY IN CYTOLOGIC SPECIMENS OF THYROID LESIONS, WITH EMPHASIS ON FOLLICULAR NEOPLASMS

被引：13

作者：

OSTROWSKI, ML

BROWN, RW

WHEELER, TM

GREEN, LK

SCHAFFNER, DL

机构：

[1] Departments of Pathology, Baylor College of Medicine

[2] Ben Taub General Hospital, Houston, Texas

来源：

DIAGNOSTIC CYTOPATHOLOGY | 1995年 / 12卷 / 04期

关键词：

THYROID; ANTI-LEU-7; ANTIBODY; FOLLICULAR NEOPLASM; FOLLICULAR CARCINOMA; FOLLICULAR ADENOMA;

D O I：

10.1002/dc.2840120403

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Anti-Leu-7 (HNK-1, CD 57) antibody, a marker for natural killer lymphocytes, was employed by Ghali et al. (Hum Pathol 1992;23: 21-25) to study surgically resected formalin-fixed, paraffin-embedded thyroid lesions. They demonstrated strong immunoreactivity of this antibody with thyroid carcinomas, both follicular and papillary, and only occasional weak immunoreactivity with colloid goiters and follicular adenomas. We studied cytologic specimens (primarily fine-needle aspiration biposy specimens) from 44 thyroid lesions, including 10 follicular carcinomas, 14 follicular adenomas, seven adenomatous nodules, six papillary carcinomas, and seven cases of Hashimoto's thyroiditis. All follicular carcinomas exhibited immunoreactivity to anti-Leu-7 antibody, usually of a moderate to strong degree (9/10); however, six of 14 follicular adenomas yielded similar results. The patterns of immunoreactivity in the other lesions were similar to those previously described (Ghali et al., Hum Pathol 1992;23:21-25). It does not appear that anti-Leu-7 antibody can be used as a specific marker of malignancy in the cytologic assessment of follicular neoplasmas of the thyroid.

引用

页码：297 / 302

页数：6

共 37 条

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