CHEMOENZYMATIC ASYMMETRIC-SYNTHESIS OF AMINO-ACIDS - ENANTIOSELECTIVE HYDROLYZES OF 2-PHENYL-OXAZOLIN-5-ONES

被引：55

作者：

GU, RL ^{[1
]}

LEE, IS ^{[1
]}

SIH, CJ ^{[1
]}

机构：

[1] UNIV WISCONSIN,SCH PHARM,MADISON,WI 53706

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 15期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(92)88111-H

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Porcine pancreatic lipase and the lipase of Aspergillus niger catalyze the enantioselective hydrolysis of a series of 4-substituted-2-phenyl-oxazolin-5-ones to yield optically active (S)- and (R)-N-benzoyl amino acids respectively.

引用

页码：1953 / 1956

页数：4

共 13 条

[1] BARRETT GC, 1985, CHEM BIOCH AMINO ACI
[2] BENOITON NL, 1983, PEPTIDES, V5, P246
[3] BEVINAKATTI HS, 1990, J CHEM SOC CHEM COMM, P1090
[4] BROCKMAN HL, 1984, LIPASES, P4
[5] ENANTIOMERIC ENRICHMENT IN THE HYDROLYSIS OF OXAZOLONES CATALYZED BY CYCLODEXTRINS OR PROTEOLYTIC-ENZYMES
DAFFE, V
FASTREZ, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (10) : 3601 - 3605
[6] ON SPECIFICITY OF PAPAIN
DEJERSEY, J
[J]. BIOCHEMISTRY, 1970, 9 (08) : 1761 - &
[7] ON SPONTANEOUS AND ENZYME-CATALYZED HYDROLYSIS OF SATURATED OXAZOLINONES
DEJERSEY, J
ZERNER, B
[J]. BIOCHEMISTRY, 1969, 8 (05) : 1967 - &
[8] Greenstein J. P., 1984, CHEM AMINO ACIDS, V1-3
[9] GREENSTEIN JP, 1984, CHEM AMINO ACIDS, V3
[10] GREENSTEIN JP, 1984, CHEM AMINO ACIDS, V2

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