INHIBITION OF PULMONARY EOSINOPHILIA AND HYPERREACTIVITY BY ANTIBODIES TO INTERLEUKIN-5

被引：65

作者：

EGAN, RW ^{[1
]}

ATHWAHL, D ^{[1
]}

CHOU, CC ^{[1
]}

EMTAGE, S ^{[1
]}

JEHN, CH ^{[1
]}

KUNG, TT ^{[1
]}

MAUSER, PJ ^{[1
]}

MURGOLO, NJ ^{[1
]}

BODMER, MW ^{[1
]}

机构：

[1] CELLTECH RES,SLOUGH,BERKS,ENGLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

关键词：

INTERLEUKIN-5; EOSINOPHILS; ASTHMA; PULMONARY INFLAMMATION; SCH; 55700;

D O I：

10.1159/000237014

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Eosinophils infiltrate into the lungs during asthma and may cause the damage associated with pulmonary inflammation. In allergic animal models, antibodies to interleukin (IL)-5 inhibit pulmonary eosinophilia, tissue damage and hyperreactivity. Sch 55700, a humanized antibody against human IL-5, inhibits eosinophilia in these models with an extended biological duration. On the basis of this dosing regimen and the humanized nature of Sch 55 700, it is anticipated that the host response leading to tolerance would be minimized.

引用

页码：321 / 322

页数：2

共 6 条

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