SYNTHESIS OF MILRINONE, A CARDIOTONIC AGENT

被引：30

作者：

SHIAO, MJ ^{[1
]}

SHYU, LM ^{[1
]}

CHEN, CF ^{[1
]}

机构：

[1] NATL RES INST CHINESE MED,TAIPEI,TAIWAN

来源：

HETEROCYCLES | 1990年 / 31卷 / 03期

关键词：

D O I：

10.3987/COM-89-5276

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthesis of milrinone (6) from 6-methyl-5-(4-pyridinyl)-2(1H-pyridone (4) is reported. A convenient synthesis of 3,4′-bipyridines (3a) and (3b) is achieved. 3a and 3b can be converted into pyridone 4 by hydrogenolysis and hydrolysis, respectively. Bromination at C-3 of the pyridone ring of 4 followed by cyanation affords milrinone (6). © 1990.

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页码：523 / 527

页数：5

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