INHIBITION OF N-NITROSOBENZYLMETHYLAMINE-INDUCED ESOPHAGEAL TUMORIGENESIS IN RATS BY ELLAGIC ACID

被引：162

作者：

MANDAL, S ^{[1
]}

STONER, GD ^{[1
]}

机构：

[1] MED COLL OHIO,DEPT PATHOL,HLTH EDUC BLDG,ROOM 202,POB 10008,TOLEDO,OH 43699

来源：

CARCINOGENESIS | 1990年 / 11卷 / 01期

关键词：

D O I：

10.1093/carcin/11.1.55

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

ln this report, we describe the ability of ellagic acid (EA), a phenolic compound present in a number of fruits and nuts, to inhibit N-nitrosobenzylmethylamnine (NEMA) twnorigenesis in the rat esophagus. When administered in a semi-purified diet at concentrations of 0.4 and 4 glkg, EA produced a significant (21-55%) decrease in the average number of NBMA-induced esophageal tumors after 20 and 27 weeks of the bioassay. FA exhibited inhibitory effects toward preneoplastic lesions as well as neoplastic lesions. Tumors were not observed in vehicle-control rats or in rats that received EA alone. © 1990 Oxford University Press.

引用

页码：55 / 61

页数：7

共 36 条

[1] AUTRUP H, 1982, CANCER RES, V42, P1307
[2] BARCH DH, 1988, CANCER RES, V48, P7088
[3] BARCH DH, 1986, J NATL CANCER I, V77, P1145
[4] BATESMITH EC, 1959, PHARM PLANT PHENOLIC, P133
[5] BLUMENBERG FW, 1960, ARZNEIMITTELFORSCH, V10, P223
[6] BULAY O, 1979, CANCER RES, V39, P3644
[7] EFFECT OF ELLAGIC ACID AND HYDROXYLATED FLAVONOIDS ON THE TUMORIGENICITY OF BENZO[A]PYRENE AND (+/-)-7-BETA,8-ALPHA-DIHYDROXY-9-ALPHA,10-ALPHA-EPOXY-7,8,9,10-TETRAHYDROBENZO[A]PYRENE ON MOUSE SKIN AND IN THE NEWBORN MOUSE
CHANG, RL
HUANG, MT
WOOD, AW
WONG, CQ
NEWMARK, HL
YAGI, H
SAYER, JM
JERINA, DM
CONNEY, AH
[J]. CARCINOGENESIS, 1985, 6 (08) : 1127 - 1133
[8] INHIBITION OF EPIDERMAL METABOLISM AND DNA-BINDING OF BENZO[A]PYRENE BY ELLAGIC ACID
DELTITO, BJ
MUKHTAR, H
BICKERS, DR
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 114 (01) : 388 - 394
[9] INHIBITION OF N-METHYL-N-NITROSOUREA-INDUCED MUTAGENICITY AND DNA METHYLATION BY ELLAGIC ACID
DIXIT, R
GOLD, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (21) : 8039 - 8043
[10] DIXIT R, 1985, CANCER RES, V45, P2951

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