SPECTROSCOPIC INVESTIGATIONS OF MALARIA PIGMENT

被引:24
作者
BREMARD, C
GIRERD, JJ
KOWALEWSKI, P
MERLIN, JC
MOREAU, S
机构
[1] INSERM,U42,F-59650 VILLENEUVE DASCQ,FRANCE
[2] UNIV PARIS 11,CHIM INORGAN LAB,CNRS,URA 420,F-91405 ORSAY,FRANCE
关键词
PLASMODIUM-FALCIPARUM; MALARIA PIGMENT; RESONANCE RAMAN SPECTROSCOPY; MAGNETIC MEASUREMENTS;
D O I
10.1366/0003702934065975
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
Malaria pigment is generated during the growth of the intraerythrocytic parasite plasmodium. This compound is postulated as a product of haemoglobin degradation and consists of an unknown iron porphyrin compound and an apoprotein. We report here a new spectroscopic investigation on the porphyrin component of intact malaria pigment obtained from in vitro cultures of Plasmodium falciparum without any previous chemical or biochemical treatment of the sample. We demonstrate the use of resonance Raman microspectrometry, electron paramagnetic resonance spectrometry, and magnetic susceptibility measurements that show the iron porphyrin moiety of the malaria pigment to be a high-spin monomeric iron(III) protoporphyrin hydroxide.
引用
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页码:1837 / 1842
页数:6
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