SIGNIFICANCE OF URINARY N-1,N-8-DIACETYLSPERMIDINE AND N-1,N-12-DIACETYLSPERMINE AS INDICATORS OF NEOPLASTIC DISEASES

被引：35

作者：

SUGIMOTO, M

HIRAMATSU, K

KAMEI, S

KINOSHITA, K

HOSHINO, M

IWASAKI, K

KAWAKITA, M

机构：

[1] TOKYO METROPOLITAN INST MED SCI,BUNKYO KU,TOKYO 113,JAPAN

[2] SELF DEF FORCE CENT HOSP,SETAGAYA KU,TOKYO 154,JAPAN

[3] TOKYO MED & DENT UNIV,FAC MED,SCH ALLIED HLTH SCI,BUNKYO KU,TOKYO 113,JAPAN

[4] TOKYO METROPOLITAN KOMAGOME HOSP,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1995年 / 121卷 / 05期

关键词：

POLYAMINE DERIVATIVES; HUMAN URINE; UROGENITAL MALIGNANCY;

D O I：

10.1007/BF01209602

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

N-1,N-8-Diacetylspermidine (Ac(2)Spd) and N-1,N-12 diacetylspermine (Ac(2)Spm), the occurrence of which in healthy human urine was demonstrated recently, increased much more frequently and markedly than total polyamines, acetylputrescine, N-1-acetylspermidine and N-8-acetylspermidine in patients with urogenital malignancies. Ac(2)Spd was hardly elevated in cases of benign disease, while Ac(2)Spm only infrequently stayed within normal limits in patients with malignant disorders. Urine samples from more than 90% of healthy persons, but fewer than 10% of patients with malignancies, gave values within normal limits for both Ac(2)Spd and Ac(2)Spm. Simultaneous reference to these diacetylpolyamines is therefore useful in distinguishing patients with malignancies from healthy persons.

引用

页码：317 / 319

页数：3

共 7 条

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