EXPRESSION OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN BREAST-CARCINOMA

被引:102
作者
LEWIS, S
LOCKER, A
TODD, JH
BELL, JA
NICHOLSON, R
ELSTON, CW
BLAMEY, RW
ELLIS, IO
机构
[1] CITY HOSP NOTTINGHAM, DEPT HISTOPATHOL, HUCKNALL RD, NOTTINGHAM NG5 1PB, ENGLAND
[2] CITY HOSP NOTTINGHAM, DEPT SURG, NOTTINGHAM NG5 1PB, ENGLAND
[3] CITY HOSP NOTTINGHAM, DEPT MED PHYS, NOTTINGHAM NG5 1PB, ENGLAND
[4] UNIV COLL CARDIFF, TENOVUS INST CANC RES, CARDIFF CF4 4XX, S GLAM, WALES
关键词
D O I
10.1136/jcp.43.5.385
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
A series of 90 patients with primary operable breast cancer and with up to 36 months of follow up were investigated for expression of epidermal growth factor receptor (EGFR) in their tumours by immunocytochemical staining with the monoclonal antibody EGFR1. Tumour samples were snap frozen in liquid nitrogen immediately after resection and subsequently stained using a standard indirect immunocytochemical method. Tumour staining was assessed by two observers and scored on a four point scale (0-3). Thirteen (14%) tumours showed positive immunoreactivity. A strong correlation between distinct EGFR expression and short disease free interval was observed. Significant correlations were also shown with oestrogen and progesterone receptor expression and tumour nuclear size. No significant association was found with tumour size, lymph node stage, and histological grade. The association with disease free interval remained significant in multivariate analysis.
引用
收藏
页码:385 / 389
页数:5
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